Articulate Storyline 3 lets you create courses that are compliant with Section 508 accessibility guidelines.
Section 508 Compliance
Storyline 3 HTML5 and Flash output supports Section 508 accessibility guidelines, including screen reader support, full keyboard navigation, visible focus indicators, and more.
To design Section 508 compliant courses, see this article for recommendations.
To review Storyline's Voluntary Product Accessibility Template (VPAT), see this article.
Accessibility How-To Articles
See these articles to learn more about authoring Section 508 compliant courses:
Screen Reader Support
Storyline 3 supports these screen readers with HTML5 and Flash courses: